Uncle Tom's Cabin; or, Life Among the Lowly is an anti-slavery novel by American author Harriet Beecher Stowe. Published in 1852, the novel had a profound effect on attitudes toward African Americans and slavery in the United States, so much in the latter case that the novel intensified the sectional conflict leading to the American Civil War.

Stowe, a Connecticut-born preacher at the Hartford Female Academy and an active abolitionist, focused the novel on the character of Uncle Tom, a long-suffering black slave around whom the stories of other charactersboth fellow slaves and slave ownersrevolve. The sentimental novel depicts the reality of slavery while also asserting that Christian love can overcome something as destructive as enslavement of fellow human beings.

Uncle Tom's Cabin was the best-selling novel of the 19th century, and the second best-selling book of that century, following the Bible.